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Biological Fluid Flows: Signaling Mediums for Circadian Timing

  • Evalien Duyvesteyn
  • Velia S. Vizcarra
  • Emma Waight
  • Estephanie Balbuena
  • Lauren M. Hablitz

Abstract

While there is extensive literature on both the neuronal circuitry of rhythms and the intracellular molecular clock, there is a large component of signaling that has been understudied: interstitial fluid (ISF)—fluid that surrounds the cells in the ...
Restricted accessResearch articleFirst published Mar 27, 2025
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Augmenting Circadian Biology Research With Data Science

  • Severine Soltani
  • Jamison H. Burks
  • Benjamin L. Smarr

Abstract

The nature of biological research is changing, driven by the emergence of big data, and new computational models to parse out the information therein. Traditional methods remain the core of biological research but are increasingly either augmented or ...
Open AccessResearch articleFirst published Jan 29, 2025
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Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation

  • Hannah M. Boyd
  • Karyn M. Frick
  • Janine L. Kwapis

Abstract

Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during complex neural processes like memory consolidation. Individually, the ...
Open AccessResearch articleFirst published Jul 19, 2023
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Circadian Regulation of the Neuroimmune Environment Across the Lifespan: From Brain Development to Aging

  • Ruizhuo Chen
  • Brandy N. Routh
  • Andrew D. Gaudet
  • Laura K. Fonken

Abstract

Circadian clocks confer 24-h periodicity to biological systems, to ultimately maximize energy efficiency and promote survival in a world with regular environmental light cycles. In mammals, circadian rhythms regulate myriad physiological functions, ...
Open AccessResearch articleFirst published Jun 26, 2023
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Molecular and Neural Mechanisms of Temperature Preference Rhythm in Drosophila melanogaster

  • Tadahiro Goda
  • Yujiro Umezaki
  • Fumika N. Hamada

Abstract

Temperature influences animal physiology and behavior. Animals must set an appropriate body temperature to maintain homeostasis and maximize survival. Mammals set their body temperatures using metabolic and behavioral strategies. The daily fluctuation in ...
Open AccessResearch articleFirst published May 24, 2023
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Circadian Control of Glial Cell Homeodynamics

  • Daniela Rojo
  • Anna Badner
  • Erin M. Gibson

Abstract

The molecular mechanisms that maintain circadian rhythms in mammalian as well as non-mammalian systems are well documented in neuronal populations but comparatively understudied in glia. Glia are highly dynamic in form and function, and the circadian ...
Available accessResearch articleFirst published Sep 6, 2022
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Circadian Interactomics: How Research Into Protein-Protein Interactions Beyond the Core Clock Has Influenced the Model of Circadian Timekeeping

  • Alexander E. Mosier
  • Jennifer M. Hurley

Abstract

The circadian clock is the broadly conserved, protein-based, timekeeping mechanism that synchronizes biology to the Earth’s 24-h light-dark cycle. Studies of the mechanisms of circadian timekeeping have placed great focus on the role that individual ...
Available accessResearch articleFirst published May 31, 2021
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Integration of Circadian Clock Information in the Drosophila Circadian Neuronal Network

  • Myra Ahmad
  • Wanhe Li
  • Deniz Top

Abstract

Circadian clocks are biochemical time-keeping machines that synchronize animal behavior and physiology with planetary rhythms. In Drosophila, the core components of the clock comprise a transcription/translation feedback loop and are expressed in seven ...
Open AccessResearch articleFirst published Mar 1, 2021
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The Circadian Clock and Viral Infections

  • Helene Borrmann
  • Jane A McKeating
  • Xiaodong Zhuang

Abstract

The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks ...
Open AccessReview articleFirst published Nov 9, 2020
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The Making and Breaking of RNAs: Dynamics of Rhythmic RNA Expression in Mammals

  • Benjamin A. Unruh
  • Shihoko Kojima

Abstract

The identification and characterization of rhythmically expressed mRNAs have been an active area of research over the past 20 years, as these mRNAs are believed to produce the daily rhythms in a wide range of biological processes. Circadian transcriptome ...
Free accessReview articleFirst published Sep 23, 2020
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