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Applied In Vitro Toxicology (AIV) This peer-reviewed journal provides the latest research on the development, validation, and application of new and innovative in vitro testing methods for predicting adverse effects of drugs, chemicals, and products in the pharmaceutical, chemical, or personal care industries. The journal addresses the issues facing these industries by including discussions on regulatory requirements; the reduction, refinement, and replacement of animal testing; new screening methods; evaluation of new cell and tissue models; and the most appropriate methods for assessing safety and satisfying regulatory demands. View full journal description

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Acknowledgment of Reviewers 2025

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From Chaos to Order: Mapping Extracted Data from Systematic Literature Reviews for Application to the AOP Framework

  • Patricia Ceger
  • Jaleh Abedini
  • Shannon Bell
  • Bethany Cook
  • Stephen Edwards
  • Virginia Hench
  • Scott G. Lynn
  • Kristan Markey
  • Sara M.F. Vliet
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Research article
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Lanternfish (Benthosema pterotum) Hydrolysates: Dual Action on Immune Regulation

  • Farzaneh Motafeghi
  • Ehsan Ghassemi Barghi
  • Jafar Gholami Gharab
  • Maryam Shokoohmand
  • Nasrin Ghassemi Barghi
Open Access
Research article
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C-DILI™ Assay: A New Mechanism-Based Human In Vitro Screen for Prediction of Cholestatic Liver Toxicity

  • Jonathan P. Jackson
  • Kenneth R. Brouwer
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Most read articles in this journal in the last 6 months.
Open Access
Research article
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A Step-by-Step Approach for Assessing Human Skin Irritation Without Animal Testing for Quasi-Drugs and Cosmetic Products

  • Hajime Kojima
  • Tokio Nakada
  • Akiko Yagami
  • Hiroaki Todo
  • Jihei Nishimura
  • Mio Yagi
  • Mariko Sugiyama
  • Keiko Yamamoto
  • Yoshiaki Ikarashi
  • Hitoshi Sakaguchi
  • Masahiko Yamaguchi
  • Morihiko Hirota
  • Hidefumi Ikeda
  • Noriyasu Imai
  • Masato Hatao
Open Access
Research article
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Preclinical Assessment of Tobacco-Free Nicotine Pouches Demonstrates Reduced In Vitro Toxicity Compared with Tobacco Snus and Combustible Cigarette Smoke

  • Fan Yu
  • Kathryn Rudd
  • Sarah Jean Pour
  • Edgar Trelles Sticken
  • Ole Dethloff
  • Roman Wieczorek
  • Thomas Nahde
  • Liam Simms
  • Fiona Chapman
  • Lukasz Czekala
  • Matthew Stevenson
  • Grant O'Connell
Open Access
Review article
First published  

Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations

  • Ghislaine Lacroix
  • Wolfgang Koch
  • Detlef Ritter
  • Arno C. Gutleb
  • Søren Thor Larsen
  • Thomas Loret
  • Filippo Zanetti
  • Samuel Constant
  • Savvina Chortarea
  • Barbara Rothen-Rutishauser
  • Pieter S. Hiemstra
  • Emeric Frejafon
  • Philippe Hubert
  • Laura Gribaldo
  • Peter Kearns
  • Jean-Marc Aublant
  • Silvia Diabaté
  • Carsten Weiss
  • Antoinette de Groot
  • Ingeborg Kooter
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Research article
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Kombucha Mushroom Extract: Anticancer, Antioxidant, and Antimicrobial Properties

  • Farzaneh Motafeghi
  • Parham Mortazavi
  • Romina Shahsavari
  • Maryam Shaker
  • Hamideh Mohammadi-Berenjestanaki
  • Mohammad Shokrzadeh
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Most cited articles published in this journal in the last 3 years. These statistics are updated weekly using data sourced exclusively from CrossRef.
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Research article
First published  

Kombucha Mushroom Extract: Anticancer, Antioxidant, and Antimicrobial Properties

  • Farzaneh Motafeghi
  • Parham Mortazavi
  • Romina Shahsavari
  • Maryam Shaker
  • Hamideh Mohammadi-Berenjestanaki
  • Mohammad Shokrzadeh
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Research article
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Protective Effect of Resveratrol on Cytotoxicity, Genotoxicity, and Oxidative Stress Caused by Cyclophosphamide and Methotrexate in Bone Marrow Stem Cell Line and Blood Lymphocytes of the Rat

  • Farzaneh Motafeghi
  • Parham Mortazavi
  • Javad Zabihi
  • Asiye Soroori
  • Pouria Samadi Mojaveri
  • Mohammad Shokrzadeh
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Research article
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The Use of Toxicokinetic Information for Setting Concentrations of In Vitro Toxicity Tests and for Interpreting Their Results: A Proposed Workflow

  • Robert Landsiedel
  • Barbara Birk
  • Philipp Demuth
  • Eric Fabian
  • Nicola J. Hewitt
  • Heli Miriam Hollnagel
  • Julia Scheel
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Articles with the highest Altmetric score from the last 3 months, indicating influence and impact.

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