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Intended for healthcare professionals

Clinical Trials is dedicated to advancing knowledge on the design and conduct of clinical trials related research methodologies. Covering the design, conduct, analysis, synthesis and evaluation of key methodologies, the journal remains on the cusp of the latest topics, including ethics, regulation and policy impact. View full journal description

This journal is a member of the Committee on Publication Ethics (COPE).

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Articles most recently published online for this journal.
Open Access
Research article
First published  

Bayesian analysis in confirmatory clinical trials: A narrative review and discussion of current practice

  • Rebecca M Turner
  • Conor D Tweed
  • Trinh Duong
  • Deborah Ford
  • Michelle N Clements
  • Mahesh KB Parmar
  • Anna Turkova
  • Ian R White
Restricted access
Research article
First published  

Evidence supporting European Medicines Agency drug approvals (2020–2023): A cross-sectional study of trial design and outcomes

  • Maximilian Siebert
  • Laura Caquelin
  • Florian Naudet
  • Joseph S Ross
  • Reshma Ramachandran
Open Access
Review article
First published  

The evolving role of placebo in non-inferiority trials: A scoping review

  • Spencer Cho
  • Shaheer Nadeem
  • Valentina Ly
  • Iman Alhafez
  • Tim Ramsay
  • Pil Joo
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Most read articles in this journal in the last 6 months.
Open Access
Research article
First published  

From RAGs to riches: Utilizing large language models to write documents for clinical trials

  • Nigel Markey
  • Ilyass El-Mansouri
  • Gaetan Rensonnet
  • Casper van Langen
  • Christoph Meier
Open Access
Research article
First published  

Estimating treatment effects in trials with outcome data truncated by death: A case study on aligning estimators with estimands

  • Tra My Pham
  • Brennan C Kahan
  • Andre Lopes
  • Memuna Rashid
  • Peter J Hoskin
  • Ian R White
Open Access
Research article
First published  

Gene-targeted therapy for neurofibromatosis and schwannomatosis: The path to clinical trials

  • Verena Staedtke
  • Kara Anstett
  • David Bedwell
  • Marco Giovannini
  • Kim Keeling
  • Robert Kesterson
  • YooRi Kim
  • Bruce Korf
  • André Leier
  • Miranda L McManus
  • Herb Sarnoff
  • Jeremie Vitte
  • James A Walker
  • Scott R Plotkin
  • Deeann Wallis
Open Access
Research article
First published  

Shaping the future of clinical trials through strategic foresight

  • Sharon Lee
  • Jeff McIntyre
  • Tracey Robertson
  • Kimberley Kallsen
  • Martin Bauer
  • Rossana Berardi
  • Christian Boisvert-Huneault
  • Emmanuelle Clerisme-Beaty
  • Christopher P Denton
  • Eric Fakra
  • Jan Geissler
  • David Goldstein
  • Kazuo Hasegawa
  • Manya Lind
  • Patricia LoRusso
  • Keith Perry
  • Claas Röhl
  • Jose Francisco Kerr Saraiva
  • Nidhi Swarup
  • Aron Szpisjak
  • Allan Flyvbjerg
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Most cited articles published in this journal in the last 3 years. These statistics are updated weekly using data sourced exclusively from CrossRef.
Open Access
Research article
First published  

Now is the time to fix the clinical research workforce crisis

  • Stephanie A Freel
  • Denise C Snyder
  • Kara Bastarache
  • Carolynn Thomas Jones
  • Mark B Marchant
  • Laura A Rowley
  • Stephen A Sonstein
  • Karen M Lipworth
  • Susan P Landis
Open Access
Research article
First published  

Using modified intention-to-treat as a principal stratum estimator for failure to initiate treatment

  • Brennan C Kahan
  • Ian R White
  • Mark Edwards
  • Michael O Harhay
Restricted access
Research article
First published  

Covariate adjustment in randomized controlled trials: General concepts and practical considerations

  • Kelly Van Lancker
  • Frank Bretz
  • Oliver Dukes
Restricted access
Research article
First published  

Overview of modern approaches for identifying and evaluating heterogeneous treatment effects from clinical data

  • Ilya Lipkovich
  • David Svensson
  • Bohdana Ratitch
  • Alex Dmitrienko
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Articles with the highest Altmetric score from the last 3 months, indicating influence and impact.

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