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Real-world evidence of the use of glucocorticoids for severe COVID-19

  • Alejandra Albarrán-Sánchez
  • Claudia Ramírez-Rentería
  • Moisés Mercado
  • Miriam Sánchez-García
  • Corazón de Jesús Barrientos-Flores
  • Aldo Ferreira-Hermosillo

Abstract

Introduction:
Currently, only glucocorticoids have proved to impact adverse outcomes in COVID-19. However, their risk/benefit balance remains inconclusive and populations’ characteristics should be considered.
Objective:
The objective was to evaluate the ...
Open AccessResearch articleFirst published Jan 19, 2022
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Recent advancement in the treatment of boys and adolescents with hypogonadism

  • Rodolfo A. Rey

Abstract

Clinical manifestations and the need for treatment varies according to age in males with hypogonadism. Early foetal-onset hypogonadism results in disorders of sex development (DSD) presenting with undervirilised genitalia whereas hypogonadism established ...
Open AccessReview articleFirst published Jan 5, 2022
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Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors

  • Asma Omran
  • Bianca M. Leca
  • Eduard Oštarijaš
  • Natasha Graham
  • Ana Sofia Da Silva
  • Zoulikha M. Zaïr
  • Alexander D. Miras
  • Carel W. le Roux
  • Royce P. Vincent
  • Linda Cardozo
  • Georgios K. Dimitriadis

Abstract

Background:
Metabolic syndrome (MetS) is defined by at least three of the following five criteria: blood pressure ⩾130/85 mmHg, fasting blood glucose ⩾5.6 mmol/l, triglycerides concentration ⩾1.7 mmol/l, waist circumference ⩾102 cm (for men), and high-...
Open AccessResearch articleFirst published Dec 8, 2021
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NAFLD in type 1 diabetes: overrated or underappreciated?

  • Jonathan Mertens
  • Luc F. Van Gaal
  • Sven M. Francque
  • Christophe De Block

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries, affecting 25–30% of the general population and up to 65% in those with obesity and/or type 2 diabetes. Accumulation of visceral adipose tissue and ...
Open AccessReview articleFirst published Nov 23, 2021
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The importance of physical activity in management of type 2 diabetes and COVID-19

  • Samuel Seidu
  • Kamlesh Khunti
  • Tom Yates
  • Abdullah Almaqhawi
  • M.J. Davies
  • Jack Sargeant

Abstract

Over time, various guidelines have emphasised the importance of physical activity and exercise training in the management of type 2 diabetes, chronic diseases, including cardiovascular disease and musculoskeletal disorders. The aim of this review is to ...
Open AccessReview articleFirst published Oct 26, 2021
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Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice

  • Najeeb Shah
  • Mohammed Altigani Abdalla
  • Harshal Deshmukh
  • Thozhukat Sathyapalan

Abstract

Diabetes mellitus (DM) is a chronic, progressive, and multifaceted illness resulting in significant physical and psychological detriment to patients. As of 2019, 463 million people are estimated to be living with DM worldwide, out of which 90% have type-2 ...
Open AccessReview articleFirst published Sep 23, 2021
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